Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Castleman's disease associated with follicular dendritic cell sarcoma and myasthenia gravis

Doença de Castleman associada a sarcoma de células dendríticas foliculares e miastenia gravis

Fernando Luiz Westphal, Luís Carlos de Lima, Luiz Carlos Lopes Santana, José Corrêa Lima Netto, Vanise Campos Gomes Amaral, Márcia dos Santos da Silva

J Bras Pneumol.2010;36(6):819-823

Abstract PDF PT PDF EN Portuguese Text

Castleman's disease is an atypical lymphoproliferative disorder of unknown etiology, which might be associated with various clinical conditions, including autoimmune diseases and malignant neoplasms. We report the case of a 72-year-old female patient who was referred to the thoracic surgery department of Getúlio Vargas University Hospital, in the city of Manaus, Brazil, for the resection of a posterior mediastinal tumor. Three months prior, the patient had been admitted to the ICU with signs of severe dyspnea, at which time she was diagnosed with myasthenia gravis. After the resection of the mediastinal tumor, the histopathological examination revealed hyaline vascular-type Castleman's disease, complicated by follicular dendritic cell sarcoma. At this writing, the patient was being treated with an anticholinesterase agent and corticosteroids for the control of myasthenia gravis.

 


Keywords: Giant lymph node hyperplasia; Dendritic cell sarcoma, follicular; Myasthenia gravis; Mediastinal diseases.

 


 

 


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