Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713


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Maternal malnutrition during lactation in Wistar rats: effects on elastic fibers of the extracellular matrix in the trachea of offspring

Desnutrição materna durante a lactação em ratos Wistar: efeitos sobre as fibras elásticas da matriz extracelular na traqueia dos filhotes

Filipe Moreira de Andrade, Luiz Felippe Judice, Gilberto Perez Cardoso, Rafael Cisne, Cristiane da Fonte Ramos, Marcio Antonio Babinski

J Bras Pneumol.2012;38(5):588-594

Abstract PDF PT PDF EN Portuguese Text

Objective: To investigate the effects of maternal protein malnutrition during lactation on the elastic fibers in the tracheas of Wistar rat pups. Methods: At delivery, 12 male pups of two Wistar rat dams were equally divided into two groups: control, in which the dam received water and standard rat chow ad libitum during lactation; and protein-restricted (PR), in which the dam received water ad libitum and an isoenergetic PR diet (8% protein). At 21 days of age, the pups were killed and their tracheas were excised. The elastic fibers were stained with Weigert's resorcin-fuchsin (after oxidation) and evaluated under light microscopy. Morphometric determinations were performed by stereology, with the point-counting method, and expressed as volumetric densities. Results: Elastic fibers, most having a longitudinal distribution, were identified beneath the tracheal mucosa. In addition, well-defined circular layers of elastic fibers were found around the inner and outer surfaces of the cartilaginous ring. There were no differences between the groups regarding the organization and distribution of the elastic fibers. The volumetric density of the elastic fibers of the pups in the control and PR groups was 2.46 ± 0.99% and 3.25 ± 1.13%, respectively (p < 0.01). Conclusions: The volumetric density of elastic fibers appears to be greater in rat pups breastfed by dams receiving a PR diet than in those breastfed by dams receiving a normal diet.


Keywords: Trachea/growth and development; Trachea/anatomy and histology; Extracellular matrix; Airway remodeling; Malnutrition.


Asymptomatic giant mediastinal mass: a rare case of thymolipoma

Massa mediastinal gigante assintomática: um raro caso de timolipoma

Omar Moté Abou Mourad, Filipe Moreira de Andrade, Pedro Abrahão, Andréa Monnerat, Luiz Felippe Judice

J Bras Pneumol.2009;35(10):1049-1052

Abstract PDF PT PDF EN Portuguese Text

Thymolipoma is a very rare benign neoplasm of the thymus. We present the case of a 42-year-old male with a massive mediastinal tumor discovered on a chest X-ray after a motorcycle accident. The patient had no complaints, and his physical examination was unremarkable. Chest CT scans revealed a lipomatous mass containing areas of soft tissue density. The patient was submitted to median sternotomy expanded to left anterolateral thoracotomy, resulting in the complete excision of the tumor. The pathological diagnosis was thymolipoma. Thymolipoma usually attains enormous dimensions by the time of diagnosis, and the occasional symptoms are related to compression of adjacent structures. Surgical resection is the treatment of choice and offers the only possibility of cure. The airway deserves special care during anesthesia induction.


Keywords: Thymus neoplasms; Mediastinal neoplasms; Thymectomy; Lipoma.


The revised tumor-node-metastasis staging system for lung cancer: changes and perspectives

Revisão do sistema de estadiamento tumor-nódulo-metástase para câncer de pulmão: mudanças e perspectivas

Filipe Moreira de Andrade, Omar Moté Abou Mourad, Luiz Felippe Judice

J Bras Pneumol.2010;36(5):617-620

Abstract PDF PT PDF EN Portuguese Text

The tumor-node-metastasis (TNM) staging system for lung cancer has been modified since its first edition in the late 1960s. Its seventh edition has been recently published and, for the first time, a truly worldwide database was analyzed in order to propose modifications in the staging. Significant changes have been made in the tumor and metastasis descriptors. Although the recommendations for the node descriptor have remained unchanged, the analysis of the factors related to this descriptor suggests that modifications will be made in the future. The forthcoming revisions of the TNM staging system might take the molecular aspects of lung cancer into consideration, aiming at a more refined staging system.


Keywords: Lung neoplasms; Neoplasm staging; Epidemiologic methods.


Trauma-related thoracoplasty: case report

Toracoplastia traumática: relato de caso

Gabriela Addor, Andreia Salarini Monteiro, David Henrique Nigri, Luiz Felippe Judice, Rui Haddad, Carlos Alberto de Barros Franco

J Bras Pneumol.2007;33(3):351-354

Abstract PDF PT PDF EN Portuguese Text

Trauma primarily affects young people and is the leading cause of death in the first three decades of life. Flail chest is observed in approximately 10% of all patients with severe chest trauma, and the mortality rate among such patients is 10-15%. We report herein the case of a car accident victim with chest trauma causing hemopneumothorax and multiple rib fractures, intense pain and deformity of the chest wall. Surgical stabilization was performed, with good results. Therapeutic options are also discussed.


Keywords: Thoracic injuries; Flail chest; Thoracoplasty.




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