Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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2015-another step along the road in a 40-year journey...

2015 - mais um passo em um caminho de 40 anos...

Rogério Souza

J Bras Pneumol.2015;41(1):1-2

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2016 - a second step

2016 - Um segundo passo

Rogerio Souza

J Bras Pneumol.2016;42(1):5-6

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The importance of strong fundamentals in scientific methodology

A importância de fundamentos robustos em metodologia científica

Rogério Souza1,2

J Bras Pneumol.2018;44(5):350-351

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The need for a balance between highly prevalent diseases and neglected diseases

A necessidade de equilíbrio entre doenças de alta prevalência e doenças negligenciadas

Rogério Souza1,2,a

J Bras Pneumol.2018;44(6):445-446

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Chronic cough in non-smokers: diagnostic approach

Abordagem diagnóstica da tosse crônica em pacientes não-tabagistas

Márcia Jacomelli, Rogério Souza, Wilson Leite Pedreira Júnior

J Bras Pneumol.2003;29(6):413-420

Abstract PDF PT

Cough is the main physiological mechanism responsible for the clearance of secretions from airways, acting as an important defense mechanism. However, the presentation of chronic cough is one of the most important causes for patients to seek medical attention all over the world, thus the significance of the correct recognition of all the factors related to the process of cough. Among those factors, some are of extreme importance, since they may be present in almost 95% of the cases: post-nasal drip syndrome, asthma and gastroesophageal reflux disease. The main step for a successful therapy for chronic cough is a rational and progressive diagnostic approach, narrowing the list of possible diagnosis and allowing the institution of a treatment with a better cost-effectiveness. The proposal of an algorithm focusing on the most common causes of chronic cough may be helpful in this initial approach.

 


Keywords: Chronic cough. Diagnostic algorithm. Asthma. Postnasal drip syndrome. Gastroesophageal reflux disease.

 


Effect of adenosine on pulmonary circulation in patients with primary pulmonary hypertension

Ação da adenosina na circulação pulmonar de pacientes com hipertensão pulmonar primária

Rogerio Souza, Marcelo Britto Passos Amato, Sergio Eduardo Demarzo, Daniel Deheinzelin, Carmen Silvia Valente Barbas, Pedro Caruso, Carlos Roberto Ribeiro Carvalho

J Bras Pneumol.2005;31(1):-

Abstract PDF PT PDF EN Portuguese Text

Background: The nucleoside adenosine is a potent vasodilator. Although its effect on the pulmonary arteries is well known, its influence on capillaries and veins has yet to be described. Objective: To evaluate the pre- and post-administration effects of adenosine on arterial and venous resistance in the pulmonary circulation of patients with primary pulmonary hypertension. Method: The study involved 7 patients with primary pulmonary hypertension and presenting a positive response to adenosine on the acute test. Before and after adenosine administration, arterial and venous resistances were determined by estimating pulmonary capillary pressure through analysis of pulmonary artery pressure decay curves. Results: Following adenosine administration, there was an increase in the cardiac index (from 1.71 ± 0.23 to 2.72 ± 0.74 L/min-1/m-2) and a decrease in pulmonary vascular resistance (from 2924 ± 1060 to 1975 ± 764 dynes/s/cm-5/m-2) with no significant variations in mean pulmonary artery pressure (pre: 75.6 ± 16.8 mmHg; post: 78.1 ± 18.8 mmHg), pulmonary wedge pressure (pre: 15.3 ± 1.5 mmHg; post: 15.4 ± 1.9 mmHg) and pulmonary capillary pressure (pre: 43.8 ± 5.8 mmHg; post: 44.5 ± 4.9 mmHg). The ratio between arterial resistance and total pulmonary vascular resistance also presented a less than significant variation (pre: 50 ± 15%; post: 49 ± 17%). These findings suggest that adenosine affects the capillaries and veins as well as the arteries. Conclusion: We can conclude that the adenosine mechanism is not restricted to the arterial aspect of the pulmonary circulation, and that analysis of pulmonary capillary pressure could prove useful in the study of various drugs that affect the pulmonary circulation.

 


Keywords: Key Words: Adenosine/pharmacocinetic. Adenosine/uso terapêutico. Blood pressure. Hypertension pulmonary.

 


Systemic corticosteroids as first-line treatment in pulmonary hypertension associated with POEMS syndrome

Corticoide sistêmico como tratamento de primeira linha da hipertensão pulmonar secundária a síndrome POEMS

Samia Rached, Rodrigo Abensur Athanazio, Sérvulo Azevedo Dias Júnior, Carlos Jardim, Rogério Souza

J Bras Pneumol.2009;35(8):804-808

Abstract PDF PT PDF EN Portuguese Text

Resumo

A síndrome POEMS é uma rara doença de plasmócitos. A ocorrência de hipertensão pulmonar como complicação respiratória da síndrome é pouco frequente e pode estar ligada ao aumento de várias citocinas, quimiocinas e fatores de crescimento como parte dos fenômenos inflamatórios que cercam a fisiopatologia da síndrome POEMS. Descrevemos o caso de uma mulher de 54 anos com síndrome POEMS e hipertensão pulmonar, que foi tratada com corticoide como terapia de primeira linha. Tratava-se de uma paciente com clássicos sintomas dessa síndrome: polineuropatia (confirmada por eletroneuromiografia), organomegalia, hipotireoidismo subclínico, gamopatia monoclonal em dosagem urinária e alterações cutâneas. A cateterização cardíaca direita revelou pressão arterial pulmonar média de 48 mmHg, débito cardíaco de 4,1 L/min e resistência vascular pulmonar de 8,05 Woods. O nível sérico de brain natriuretic peptide (BNP) foi de 150 pg/mL. Nenhuma outra doença foi encontrada durante investigação. Prednisona (1 mg/kg por três meses) foi iniciada, com dramática melhora clínica e funcional, além de normalização dos níveis dos hormônios tireoidianos e de proteína em urina por eletroforese. A pressão arterial pulmonar média caiu para 26 mmHg, o débito cardíaco para 3,8 L/min e a resistência vascular pulmonar para 2,89 Woods. O nível sérico de BNP caiu para 8pg/mL. Nossos achados indicam o potencial papel da corticoterapia como primeira linha de tratamento na hipertensão pulmonar associada à síndrome POEMS. Diante da raridade dessa apresentação, um registro multicêntrico deveria ser desenvolvido para permitir a aquisição de mais dados que suportem essa conduta.

 


Palavras-chave: Síndrome POEMS; Hipertensão pulmonar; Glucocorticoides.

 


Left ventricular dysfunction in patients with suspected pulmonary arterial hypertension

Disfunção ventricular esquerda em pacientes com suspeita de hipertensão arterial pulmonar

Francisca Gavilanes, José Leonidas Alves Jr, Caio Fernandes, Luis Felipe Lopes Prada, Carlos Viana Poyares Jardim, Luciana Tamie Kato Morinaga, Bruno Arantes Dias, Susana Hoette, Rogerio Souza

J Bras Pneumol.2014;40(6):609-616

Abstract PDF PT PDF EN Portuguese Text

Objective: To evaluate the role of right heart catheterization in the diagnosis of pulmonary arterial hypertension (PAH). Methods: We evaluated clinical, functional, and hemodynamic data from all patients who underwent right heart catheterization because of diagnostic suspicion of PAH-in the absence of severe left ventricular dysfunction (LVD), significant changes in pulmonary function tests, and ventilation/perfusion lung scintigraphy findings consistent with chronic pulmonary thromboembolism-between 2008 and 2013 at our facility. Results: During the study period, 384 patients underwent diagnostic cardiac catheterization at our facility. Pulmonary hypertension (PH) was confirmed in 302 patients (78.6%). The mean age of those patients was 48.7 years. The patients without PH showed better hemodynamic profiles and lower levels of B-type natriuretic peptide. Nevertheless, 13.8% of the patients without PH were categorized as New York Heart Association functional class III or IV. Of the 218 patients who met the inclusion criteria, 40 (18.3%) and 178 (81.7%) were diagnosed with PH associated with LVD (PH-LVD) and with PAH, respectively. The patients in the HP-LVD group were significantly older than were those in the PAH group (p < 0.0001). Conclusions: The proportional difference between the PAH and PH-LVD groups was quite significant, considering the absence of echocardiographic signs suggestive of severe LVD during the pre-catheterization investigation. Our results highlight the fundamental role of cardiac catheterization in the diagnosis of PAH, especially in older patients, in whom the prevalence of LVD that has gone undiagnosed by non-invasive tests is particularly relevant.

 


Keywords: Hypertension, pulmonary; Cardiac catheterization, Ventricular dysfunction, left.

 


Pulmonary veno-occlusive disease: diagnostic and therapeutic alternatives

Doença veno-oclusiva pulmonar: alternativas diagnósticas e terapêuticas

Carlos Eduardo Galvão Barboza, Carlos Viana Poyares Jardim, André Luís Dressler Hovnanian, Bruno Arantes Dias, Rogério Souza

J Bras Pneumol.2008;34(9):749-752

Abstract PDF PT PDF EN Portuguese Text

Pulmonary veno-occlusive disease (PVOD) is a rare cause of pulmonary hypertension. Surgical biopsy was usually required for diagnostic confirmation. However, the morbidity, mortality and limited benefit of this procedure have generated discussion regarding noninvasive diagnostic techniques. We present the case of a female patient with progressive dyspnea, hypoxemia and pulmonary hypertension, the last diagnosed via catheterization. Computed tomography revealed septal thickening and diffuse micronodules. Bronchoalveolar lavage revealed occult alveolar hemorrhage. Treatment with an endothelin antagonist was started, resulting in symptomatic and functional improvement. Occult alveolar hemorrhage differentiates PVOD from idiopathic pulmonary hypertension. We believe that this finding, in combination with characteristic tomographic findings, is sufficient to establish a diagnosis of PVOD.

 


Keywords: Hypertension, pulmonary; Pulmonary veno-occlusive disease; Bronchoalveolar lavage; Receptors, endothelin/antagonists & inhibitors.

 


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Edital de Seleção

Fernando Lundgren, Rogerio Souza

J Bras Pneumol.2017;43(3):-

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Alveolar hemorrhage associated with lupus nephritis

Hemorragia alveolar associada a nefrite lúpica

Ricardo Henrique de Oliveira Braga Teixeira, Marcel Hiratsuka, Flávia Calderini Rosa, Rogério Souza, Carlos Roberto Ribeiro de Carvalho

J Bras Pneumol.2003;29(6):401-404

Abstract PDF PT

Alveolar hemorrhage leading to respiratory failure is uncommon. Various etiologies have been reported, including systemic lupus erythematosus, which generally presents as pulmonary-renal syndrome. It is believed that the pathogenesis of microangiopathy is related to deposits of immune complexes that lead to activation of cellular apoptosis. The authors report two cases of alveolar hemorrhage and respiratory failure, both requiring mechanical ventilation. The two cases had opposite outcomes after pharmacological therapy. The presence of anti-glomerular basement membrane antibodies in one of the cases demonstrates the multiplicity of physiopathological mechanisms that may be involved. This multiplicity of mechanisms provides a possible explanation for the heterogeneous responses to the available treatments.

 


Keywords: Lupus erythematosus systemic/etiology. Lupus nephritis/etiology. Respiratory insufficiency/complications.

 


Chronic thromboembolic pulmonary hypertension: diagnostic limitations

Hipertensão pulmonar associada ao tromboembolismo pulmonar crônico: limitações diagnósticas

Bruno Arantes Dias, Carlos Jardim, André Hovnanian, Caio Júlio César Fernandes, Rogério Souza

J Bras Pneumol.2008;34(7):532-536

Abstract PDF PT PDF EN Portuguese Text

Chronic thromboembolic pulmonary hypertension is the only potentially curable form of pulmonary hypertension, assuming that surgical treatment is possible. However, there are hindrances to making a definitive, noninvasive diagnosis. We present the case of a 40-year-old female patient with idiopathic pulmonary arterial hypertension, confirmed in 1994. This patient developed thrombi in pulmonary vessels (as an overlap syndrome) mimicking chronic thromboembolic pulmonary hypertension. The identification of these conditions, which present high intraoperative mortality and unsatisfactory surgical resolution, is quite difficult in clinical practice. We discuss the current approach to candidate selection for surgical treatment of chronic thromboembolic pulmonary hypertension and the possible repercussions of inappropriate selection.

 


Keywords: Hypertension, pulmonary/diagnosis; Hypertension, pulmonary/therapy; Pulmonary embolism; Endarterectomy.

 


Incidence of spontaneous subdural hematoma in incident cases of pulmonary arterial hypertension: a registry of cases occurring over a five-year period

Incidência de hematomas subdurais espontâneos em casos de pacientes com hipertensão arterial pulmonar: análise de um registro de cinco anos

Luis Felipe Lopes Prada, Francisca Gavilanes, Rogério Souza

J Bras Pneumol.2015;41(1):101-102

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JBP and bibliometric indices

JBP e os índices bibliométricos

Rogério Souza

J Bras Pneumol.2017;43(4):247-248

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Smoke inhalation injury

Lesão por inalação de fumaça

Rogério Souza, Carlos Jardim, João Marcos Salge, Carlos Roberto Ribeiro Carvalho

J Bras Pneumol.2004;30(6):557-565

Abstract PDF PT PDF EN

Inhalation injury is the main cause of death in burn patients and has therefore, understandably, been the subject of numerous published studies. The pathogenesis of inhalation injury involves both local and systemic mechanisms, thereby increasing the repercussions of the injury. The search for tools that would allow earlier diagnosis of inhalation injury and for treatment strategies to lessen its deleterious effects is ongoing. In this review, we describe the physiopathological mechanisms of inhalation injury, as well as the current diagnostic tools and treatment strategies used in patients suffering from inhalation injury. We also attempt to put experimental therapeutic approaches into perspective.

 


Keywords: Smoke inhalation injury/diagnosis. Smoke inhalation injury/pathophysiology. Smoke inhalation injury/ complications. Burns, inhalation/therapy. Review literature. Carbon monoxide. Poisoning/complications.

 


Momentum

Momentum

Rogério Souza1,2

J Bras Pneumol.2017;43(5):327-327

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New steps for the international consolidation of the Brazilian Journal of Pulmonology

Novos passos para a consolidação internacional do Jornal Brasileiro de Pneumologia

Carlos Roberto Ribeiro Carvalho, Bruno Guedes Baldi, Carlos Viana Poyares Jardim, Pedro Caruso, Rogério Souza

J Bras Pneumol.2014;40(4):325-326

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Bringing the JBP and its readers closer together

O JBP mais próximo do leitor

Rogério Souza1

J Bras Pneumol.2015;41(3):209-210

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The role of imaging techniques in the assessment of pulmonary circulation

O papel dos exames de imagem na avaliação da circulação pulmonar

André Hovnanian, Eduardo Menezes, Susana Hoette, Carlos Jardim, Dany Jasinowodolinski, Rogério Souza

J Bras Pneumol.2011;37(3):389-403

Abstract PDF PT PDF EN Portuguese Text

Knowledge of the structure and function of pulmonary circulation has evolved considerably in the last few decades. The use of non-invasive imaging techniques to assess the anatomy and function of the pulmonary vessels and heart has taken on added importance with the recent advent of novel therapies. Imaging findings not only constitute a diagnostic tool but have also proven to be essential for prognosis and treatment follow-up. This article reviews the myriad of imaging methods currently available for the assessment of pulmonary circulation, from the simple chest X-ray to techniques that are more complex and promising, such as electrical impedance tomography.

 


Keywords: Pulmonary circulation; Diagnostic imaging; Hypertension, pulmonary.

 


New anticoagulants for the treatment of venous thromboembolism

Os novos anticoagulantes no tratamento do tromboembolismo venoso

Caio Julio Cesar dos Santos Fernandes1, José Leonidas Alves Júnior1, Francisca Gavilanes1, Luis Felipe Prada1, Luciana Kato Morinaga1, Rogerio Souza1

J Bras Pneumol.2016;42(2):146-154

Abstract PDF PT PDF EN Portuguese Text

Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in particular. Over the past decades, new classes of anticoagulants have been developed, such as factor Xa inhibitors and direct thrombin inhibitors, which significantly changed the therapeutic arsenal against VTE, due to their efficacy and safety when compared with the conventional treatment. The focus of this review was on evaluating the role of these new anticoagulants in this clinical context.

 


Keywords: Blood coagulation; Venous thromboembolism\therapy; Venous thromboembolism\prevention and control.

 


The next 40 years

Os próximos 40 anos

Rogério Souza¹

J Bras Pneumol.2015;41(5):404-404

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Resolution of right-to-left shunt after primary pulmonary hypertension treatment with sildenafil

Resolução do "shunt" direita-esquerda após uso do sildenafil como tratamento de hipertensão pulmonar primária

Sérgio Marques da Silva, Carla Bastos Valeri, Humberto Bassit Bogossian, Carlos Jardim, Sérgio Eduardo Demarzo, Rogério Souza

J Bras Pneumol.2003;29(5):305-308

Abstract PDF PT

Primary pulmonary hypertension is a rare, progressive disease with high mortality rates. The treatment of primary pulmonary hypertension is still based on high-cost drugs, not yet available in developing countries. Recently, the use of sildenafil as an alternative drug for primary pulmonary hypertension treatment has been reported. It is reported a case of a 21 year-old female patient with primary pulmonary hypertension, who presented an acute worsening of symptoms and decrease of oxygen saturation. The investigation revealed the existence of a patent oval foramen not previously seen, with right-to-left shunt. Sildenafil treatment was instituted in escalating doses. After 40 days of treatment, the echocardiogram showed resolution of the shunt, concomitant to oxygenation improvement. The authors believe that sildenafil is a feasible alternative for primary pulmonary hypertension treatment, although larger clinical trials are necessary to determine its clinical safety and efficacy.

 


Keywords: Pulmonary hypertension/therapy. Vasodilator agents/administration & dosage.

 


Consolidating in the present, with an eye to the future

Sedimentando o presente, visando o futuro

Rogerio Souza

J Bras Pneumol.2016;42(6):399-400

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Lodenafil treatment in the monocrotaline model of pulmonary hypertension in rats

Tratamento com lodenafila no modelo de hipertensão pulmonar induzida por monocrotalina em ratos

Igor Bastos Polonio, Milena Marques Pagliareli Acencio, Rogério Pazetti, Francine Maria de Almeida, Bárbara Soares da Silva, Karina Aparecida Bonifácio Pereira, Rogério Souza

J Bras Pneumol.2014;40(4):421-424

Abstract PDF PT PDF EN Portuguese Text

We assessed the effects of lodenafil on hemodynamics and inflammation in the rat model of monocrotaline-induced pulmonary hypertension (PH). Thirty male Sprague-Dawley rats were randomly divided into three groups: control; monocrotaline (experimental model); and lodenafil (experimental model followed by lodenafil treatment, p.o., 5 mg/kg daily for 28 days) Mean pulmonary artery pressure (mPAP) was obtained by right heart catheterization. We investigated right ventricular hypertrophy (RVH) and IL-1 levels in lung fragments. The number of cases of RVH was significantly higher in the monocrotaline group than in the lodenafil and control groups, as were mPAP and IL-1 levels. We conclude that lodenafil can prevent monocrotaline-induced PH, RVH, and inflammation.

 


Keywords: Hypertension, pulmonary; Monocrotaline; Interleukin-1.

 


Validation of a treadmill six-minute walk test protocol for the evaluation of patients with pulmonary arterial hypertension

Validação de um protocolo para o teste de caminhada de seis minutos em esteira para avaliação de pacientes com hipertensão arterial pulmonar

Viviane Moreira de Camargo, Barbara do Carmo dos Santos Martins, Carlos Jardim, Caio Julio Cesar Fernandes, Andre Hovnanian, Rogério Souza

J Bras Pneumol.2009;35(5):423-430

Abstract PDF PT PDF EN Portuguese Text

Objective: To develop and validate a protocol for the treadmill six-minute walk test (tread6MWT) to evaluate patients with pulmonary arterial hypertension (PAH). Methods: The study population comprised 73 patients with PAH, diagnosed by means of right heart catheterization, with or without NO inhalation. All patients performed a hallway 6MWT and three tread6MWTs based on a pre-determined incremental speed protocol and interposed by a rest period. The patients who had been submitted to hemodynamic testing using NO performed the third tread6MWT while inhaling the same dose of NO that had been used during the catheterization. Results: We found that the treadmill six-minute walk distance (tread6MWD) correlated with hemodynamic data, functional class and the hallway six-minute walk distance (6MWD). In addition, the tread6MWD correlated significantly with survival, thereby confirming the correlation with disease severity. Inhalation of NO during the tread6MWT led to variations that were consistent with the hemodynamic changes induced by the same dose of inhaled NO, suggesting that the protocol developed can reflect the effect of therapeutic interventions. Conclusions: We conclude that the tread6MWD is a useful prognostic and functional marker for the routine evaluation of PAH patients.

 


Keywords: Hypertension, pulmonary; Exercise test; Hemodynamics.

 


 

 


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