Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713


Publication continuous and bimonthly

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Giant pulmonary artery aneurysm in a patient with schistosomiasis-associated pulmonary arterial hypertension

Aneurisma gigante da artéria pulmonar em paciente com hipertensão arterial pulmonar associada à esquistossomose

Francisca Gavilanes1,a, Bruna Piloto1,b, Caio Julio Cesar Fernandes1,c

J Bras Pneumol.2018;44(2):167-167

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New anticoagulants for the treatment of venous thromboembolism

Os novos anticoagulantes no tratamento do tromboembolismo venoso

Caio Julio Cesar dos Santos Fernandes1, José Leonidas Alves Júnior1, Francisca Gavilanes1, Luis Felipe Prada1, Luciana Kato Morinaga1, Rogerio Souza1

J Bras Pneumol.2016;42(2):146-154

Abstract PDF PT PDF EN Portuguese Text

Worldwide, venous thromboembolism (VTE) is among the leading causes of death from cardiovascular disease, surpassed only by acute myocardial infarction and stroke. The spectrum of VTE presentations ranges, by degree of severity, from deep vein thrombosis to acute pulmonary thromboembolism. Treatment is based on full anticoagulation of the patients. For many decades, it has been known that anticoagulation directly affects the mortality associated with VTE. Until the beginning of this century, anticoagulant therapy was based on the use of unfractionated or low-molecular-weight heparin and vitamin K antagonists, warfarin in particular. Over the past decades, new classes of anticoagulants have been developed, such as factor Xa inhibitors and direct thrombin inhibitors, which significantly changed the therapeutic arsenal against VTE, due to their efficacy and safety when compared with the conventional treatment. The focus of this review was on evaluating the role of these new anticoagulants in this clinical context.


Keywords: Blood coagulation; Venous thromboembolism\therapy; Venous thromboembolism\prevention and control.




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