Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Prevalence of latent Mycobacterium tuberculosis infection in prisoners

Prevalência da infecção latente por Mycobacterium tuberculosis em pessoas privadas de liberdade

Pedro Daibert de Navarro1,2, Isabela Neves de Almeida1, Afrânio Lineu Kritski3, Maria das Graças Ceccato4, Mônica Maria Delgado Maciel1, Wânia da Silva Carvalho4, Silvana Spindola de Miranda5

J Bras Pneumol.2016;42(5):348-355

Abstract PDF PT PDF EN Portuguese Text

Objective: To determine the prevalence of and the factors associated with latent Mycobacterium tuberculosis infection (LTBI) in prisoners in the state of Minas Gerais, Brazil. Methods: This was a cross-sectional cohort study conducted in two prisons in Minas Gerais. Tuberculin skin tests were performed in the individuals who agreed to participate in the study. Results: A total of 1,120 individuals were selected for inclusion in this study. The prevalence of LTBI was 25.2%. In the multivariate analysis, LTBI was associated with self-reported contact with active tuberculosis patients within prisons (adjusted OR = 1.51; 95% CI: 1.05-2.18) and use of inhaled drugs (adjusted OR = 1.48; 95% CI: 1.03-2.13). Respiratory symptoms were identified in 131 (11.7%) of the participants. Serological testing for HIV was performed in 940 (83.9%) of the participants, and the result was positive in 5 (0.5%). Two cases of active tuberculosis were identified during the study period. Conclusions: Within the prisons under study, the prevalence of LTBI was high. In addition, LTBI was associated with self-reported contact with active tuberculosis patients and with the use of inhaled drugs. Our findings demonstrate that it is necessary to improve the conditions in prisons, as well as to introduce strategies, such as chest X-ray screening, in order to detect tuberculosis cases and, consequently, reduce M. tuberculosis infection within the prison system.

 


Keywords: Prisons; Tuberculin test; Latent tuberculosis, HIV.

 


Prevalence of latent Mycobacterium tuberculosis infection in renal transplant recipients

Prevalência da infecção latente por Mycobacterium tuberculosis em transplantados renais

Mônica Maria Moreira Delgado Maciel1,2,a, Maria das Graças Ceccato3,b, Wânia da Silva Carvalho3,c, Pedro Daibert de Navarro1,d, Kátia de Paula Farah1,e, Silvana Spindola de Miranda1,f

J Bras Pneumol.2018;44(6):461-467

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Objective: To estimate the prevalence of latent Mycobacterium tuberculosis infection (LTBI) in renal transplant recipients and to assess sociodemographic, behavioral, and clinical associations with positive tuberculin skin test (TST) results. Methods: This was a cross-sectional study of patients aged ≥ 18 years who underwent renal transplantation at the Renal Transplant Center of the Federal University of Minas Gerais Hospital das Clínicas, located in the city of Belo Horizonte, Brazil. We included renal transplant recipients who underwent the TST between January 2011 and July 2013. If the result of the first TST was negative, a second TST was administered. Bivariate and multivariate analyses using logistic regression were used to determine factors associated with positive TST results. Results: The sample included 216 patients. The prevalence of LTBI was 18.5%. In the multivariate analysis, history of contact with a tuberculosis case and preserved graft function (estimated glomerular filtration rate ≥ 60 mL/min/1.73 m2) were associated with positive TST results. TST induration increased by 5.8% from the first to the second test, which was considered significant (p = 0.012). Conclusions: The prevalence of LTBI was low in this sample of renal transplant recipients. The TST should be administered if renal graft function is preserved. A second TST should be administered if the first TST is negative.

 


Keywords: Tuberculosis; Tuberculin test; Immunocompromised host.

 


 

 


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