Brazilian Journal of Pulmonology

ISSN (on-line): 1806-3756 | ISSN (printed): 1806-3713

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Acute respiratory failure as a manifestation of eosinophilia-myalgia syndrome associated with L-tryptophan intake

Insuficiência respiratória aguda como manifestação da síndrome de eosinofilia-mialgia associada à ingestão de L-triptofano

Tiago de Araujo Guerra Grangeia, Marcelo Schweller, Ilma Aparecida Paschoal, Lair Zambon, Mônica Corso Pereira

J Bras Pneumol.2007;33(6):747-751

Abstract PDF PT PDF EN Portuguese Text

Eosinophilia-myalgia syndrome was described in 1989 in patients who presented progressive and incapacitating myalgia and eosinophilia in blood, fluids and secretions. Most patients report previous L-tryptophan intake. Respiratory manifestations are found in up to 80% of the cases, occasionally as the only manifestation. Treatment includes drug discontinuation and administration of corticosteroids. Here, we describe the case of a 61-year-old female admitted with acute respiratory failure after using L-tryptophan, hydroxytryptophan and other drugs. The patient presented eosinophilia, together with elevated eosinophil counts in the bronchoalveolar lavage and pleural effusion. After discontinuation of the drugs previously used, corticosteroids were administered, resulting in clinical and radiological improvement within just a few days.

 


Keywords: Respiratory insufficiency; Tryptophan; Eosinophilia-myalgia syndrome.

 


Rheumatoid pneumoconiosis (Caplan's syndrome) with a classical presentation

Pneumoconiose reumatoide (síndrome de Caplan) com apresentação clássica

Eduardo Mello De Capitani, Marcelo Schweller, Cristiane Mendes da Silva, Konradin Metze, Elza Maria Figueiras Pedreira de Cerqueira, Manoel Barros Bértol

J Bras Pneumol.2009;35(9):942-946

Abstract PDF PT PDF EN Portuguese Text

Although rare, rheumatoid pneumoconiosis, also known as Caplan's syndrome, can occur in workers exposed to silica, as well as in patients with silicosis, coal workers' pneumoconiosis or asbestosis. Prevalence is higher among patients with silicosis, despite the fact that it was originally described in coal workers with pneumoconiosis. The classical finding that defines this syndrome is that of rheumatoid nodules in the lungs, regardless of whether there are small rounded opacities suggestive of pneumoconiosis or large opacities consistent with massive pulmonary fibrosis, with or without clinical rheumatoid arthritis. We describe the case of a female patient with rheumatoid arthritis, diagnosed 34 years after 7 years of occupational exposure to silica at a porcelain plant. A chest X-ray showed circular opacities of 1-5 cm in diameter, bilaterally distributed at the periphery of the lungs. A CT-guided thoracic punch biopsy of one of those nodules revealed that it was rheumatoid nodule surrounded by a palisade of macrophages, which is typical of Caplan's syndrome. Aspects of diagnosis, classification and occurrence of this syndrome are discussed, emphasizing the importance of the occupational anamnesis of patients with rheumatoid arthritis and lung opacities on chest X-rays.

 


Keywords: Pneumoconiosis; Arthritis, rheumatoid; Caplan's syndrome; Silicosis.

 


 

 


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